Involvement of T-complex protein 1-ring complex/chaperonin containing T-complex protein 1 (TRiC/CCT) in retrograde axonal transport through tau phosphorylation
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چکیده
منابع مشابه
BAG-1 associates with Hsc70.Tau complex and regulates the proteasomal degradation of Tau protein.
Intraneuronal accumulation of phosphorylated Tau protein is a molecular pathology found in many forms of dementia, including Alzheimer disease. Research into possible mechanisms leading to the accumulation of modified Tau protein and the possibility of removing Tau protein from the system have revealed that the chaperone protein system can interact with Tau and mediate its degradation. Hsp70/Hs...
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ژورنال
عنوان ژورنال: Neural Regeneration Research
سال: 2019
ISSN: 1673-5374
DOI: 10.4103/1673-5374.247460